Recognition and quantitation of the components in a fake Vietnamese natural medication against rheumatic diseases

Fake or unlawfully produced medication and natural supplements are becoming an improving problem throughout the world. Internet revenue make simpler submission and transaction of these falsified medication. Here we review on a Vietnamese natural medication, which was promoted for therapy of rheumatic illness from a spiritual Vietnamese healbot. Through NMR and LC/MS we discovered 863 mg acetaminophen, 262 mg sulfamethoxazole, 42 mg indomethacin and less than 1% trimethoprim in a sachet of 2.617 g powdered material, moreover to some nutmeg debris and phosphate.

Individuals affected by rheumatic illnesses are influenced to buyherbal medications because the antirheumatic treatment with chemicaldrugs is associated with regularly happening powerful adverse reactions,e.g. due to gastro-intestinal blood loss. Going to the world wide web revealsa large choice of herbals against joint disease type Asiancountries, such as Chinese suppliers, Native indian (TCM, Ayurvedic, Unani or Tibbi), andKorea. For many Native indian herbals, the medicinal activityis well-described, e.g. Other herbals are of low great quality and ille-gal, and probably risky for the sufferers. Moreover, a lotof so-called herbals, available in the world wide web, contain chemicallydefined medication beside herbals, e.g. in the area of way of life drugssuch as cialis and sildenafil. Here, the substance medication ismostly not marked.Counterfeit and/or unlawfully produced medication and  herbalmedicines are becoming an improving issue throughout theworld.

The issue is well recorded in the literary works. Unravelling the counterfeiting by recognition of the ingredientsof the (herbal) medication is always a task. Mostly a combina-tion of many spectroscopic methods such as great performanceliquid chromatography hyphenated with large spectrometry and NMR spectroscopy is necessary for recognition and quantifica-tion of the effective drug elements in additionto unique methods as DOSY1H NMR. Lately, we got such an organic medication from a women rheumaticpatient who purchased the medication from a spiritual Vietnamesehealer. It was promoted as 100% organic and associated bythe guidance to take one sachet per day. A sachet included 2.6 gof a darkish powdered, smell of nutmeg. Unfortunately, nolabeling was discovered. For recognition and quantification of theingredients HPLC–UV and –MS, NMR and IR assessments as wellas some inorganic assessments were used, in inclusion mild microscopestudies to elucidate the 100 % organic components.

Title Post: Recognition and quantitation of the components in a fake Vietnamese natural medication against rheumatic diseases
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